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durch  |  22-Apr-2017 00:00

Full figure and legend (97There are a number of ways of obtaining genes encoding tumor-reactive TCR.

Some antigens are considered relatively immunogenic, and specific TCR can be derived from spontaneously occurring tumor-specific T cells in patients.

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A tumor cell is shown (center) that expresses an antigen, which can be expressed in its native form on the cell surface or as peptide fragments in the context of major histocompatibility complex I (MHCI) molecules following processing intracellularly by the proteosome, endoplasmic reticulum (ER) and Golgi.

(a) Cell surface antigen can be recognized by a CAR expressed by T cells.

Lymphocytes of the immune system can eliminate disease with exquisite specificity.

This specificity is mediated by antigen receptors expressed by T cells and B cells.

However, it is possible to obtain TCRs specific for such antigens using several ingenious methods.

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